![]() The aim of this study is to evaluate whether a combination of PS with ATC is superior to PS alone in weaning patients with severe neurotoxic snake envenoming. Recently, we have reported our ICU data of 55 patients of severe neurotoxic snake envenoming in which we evaluated if usage of a higher dosage of SAV offered any significant clinical advantage over a lower dose, and found no difference between the high-dose and low-dose groups. Medical advances have shortened what used to be a year-long recovery into a now typical 2-3 month timeframe. This mode theoretically can decrease weaning duration and increase the probability of successful extubation by decreasing the WOB. ![]() However, a new mode of ventilatory support called automatic tube compensation (ATC) delivers exactly the amount of pressure necessary to overcome the resistive load imposed by the endotracheal tube for the flow measured at the time (so called variable pressure support). Commonly used maneuvers to overcome the ETT resistance include the use of continuous positive airway pressure (CPAP) or pressure support (PS). In the mechanically ventilated patient, it has long been recognized that the single greatest cause of imposed work of breathing (WOB) is the resistance caused by the endotracheal tube (ETT). ![]() This process is not only difficult in patients with chronic respiratory diseases and neuromuscular disorders like neurotoxic snake bite, but is also associated with significant complications like pneumonia, prolonged ICU stay and even mortality, especially in those with persistent weaning failure. However, approximately 20-30% of patients still require gradual discontinuation i.e. Mechanical ventilation is a life-saving intervention and once there is improvement of the underlying indication for mechanical ventilation, it can be withdrawn abruptly in the majority. Respiratory failure, requiring mechanical ventilatory support, is a frequent cause for admission to the intensive care unit (ICU). Coast Guard E-9 Senior Enlisted Member) MedEvac Medical evacuation. Military) MCPO Master Chief Petty Officer (USCG/USN E-9) MCPOCG Master Chief Petty Officer of the Coast Guard (U.S. Military) MCEITS Marine Corps Enterprise Information Technology Service (U.S. The Anatomical Therapeutic Chemical code: a unique code assigned to a medicine according to the organ or system it works on and how it works. The management of these patients includes ventilatory support and administration of snake anti-venom (SAV). MCEN Marine Corps Enterprise Network (U.S. The bites of Elapid snakes cause predominantly neurotoxicity, which manifests as paralysis of the muscles of the eyes, tongue, throat and respiration, leading to respiratory failure, and if untreated death. Snake envenoming is a common medical emergency encountered in the tropical countries, and an estimated 35,000 to 50,000 people die of snake bite every year in India.
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